Abdulkareem Imran Haruna
Department of Trauma and Orthopaedic Surgery, Leeds University Teaching Hospital, Leeds, UK.
Niger Med J. 2013 Nov;54(6):371-5. doi: 10.4103/0300-1652.126284.
This is a literature review on the aetiology and pathogenesis of breast cancer, which is the most common cancer worldwide, and the second leading cause of cancer death, especially in Western countries. Several aetiological factors have been implicated in its pathogenesis, and include age, genetics, family history, diet, alcohol, obesity, lifestyle, physical inactivity, as well as endocrine factors. These factors act separately or together in the causation of breast cancer. More recently, triple negative breast cancer has been described in certain categories of patients and is associated with poorer prognosis and earlier recurrence compared with the conventional breast cancer. Therefore, adequate knowledge of these factors is important in identifying high risk groups and individuals, which will help in screening, early detection and follow-up. This will help to decrease the morbidity and mortality from this life-threatening disease.
这是一篇关于乳腺癌病因和发病机制的文献综述。乳腺癌是全球最常见的癌症，也是癌症死亡的第二大主要原因，尤其在西方国家。其发病机制涉及多个病因学因素，包括年龄、遗传、家族史、饮食、酒精、肥胖、生活方式、缺乏身体活动以及内分泌因素。这些因素在乳腺癌的发生中单独或共同起作用。最近，在某些类型的患者中发现了三阴性乳腺癌，与传统乳腺癌相比，其预后较差且复发较早。因此，充分了解这些因素对于识别高危群体和个体很重要，这将有助于筛查、早期发现和随访。这将有助于降低这种危及生命的疾病的发病率和死亡率。
