系统性红斑狼疮中的多种血管病变及其临床意义。
Diverse vascular lesions in systemic lupus erythematosus and clinical implications.
作者信息
Tan Ying, Yu Feng, Liu Gang
机构信息
aRenal Division, Department of Medicine, Peking University First Hospital bInstitute of Nephrology, Peking University cKey Laboratory of Renal Disease, Ministry of Health of China dKey Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, PR China *Ying Tan and Feng Yu contributed equally to the writing of this article.
出版信息
Curr Opin Nephrol Hypertens. 2014 May;23(3):218-23. doi: 10.1097/01.mnh.0000444812.65002.cb.
PURPOSE OF REVIEW
Vascular injury is one of the typical symptoms of systemic lupus erythematosus (SLE), and may play a key role in the choice of treatment strategy and prediction of prognosis. In this review, diverse vascular lesions in SLE and their clinical significance are discussed.
RECENT FINDINGS
The clinical features of vascular disease in SLE differ from organ to organ, and may be extreme with regard to renal vascular lesions. Vascular lesions in SLE may be of inflammatory or thrombotic origin, and immune system dysfunction is considered to be a predominant feature. Numerous lines of evidence suggest that the activation and injury of endothelial cells might play a key role in the pathogenesis.
SUMMARY
Vascular lesions in SLE are mediated by a complex interaction between the immune system and other contributing factors. Different therapies developed for vascular lesions, both immunosuppressive and nonimmunosuppressive, should be selected based on the different clinical and pathological characteristics, and our future understanding of the different mechanisms involved.
综述目的
血管损伤是系统性红斑狼疮（SLE）的典型症状之一，可能在治疗策略的选择和预后预测中起关键作用。在本综述中，将讨论SLE中各种血管病变及其临床意义。
最新发现
SLE血管疾病的临床特征因器官而异，在肾血管病变方面可能尤为明显。SLE中的血管病变可能源于炎症或血栓形成，免疫系统功能障碍被认为是主要特征。大量证据表明，内皮细胞的激活和损伤可能在发病机制中起关键作用。
总结
SLE中的血管病变是由免疫系统与其他相关因素之间的复杂相互作用介导的。应根据不同的临床和病理特征以及我们对所涉及的不同机制的未来理解，选择针对血管病变开发的不同治疗方法，包括免疫抑制和非免疫抑制治疗。
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