Ibrayeva A, Kozhamkulov U, Raiymbek D, Alenova A, Igilikova S, Zholdybayeva E, Abildaev T, Momynaliev K
National Center for Biotechnology, Astana, Kazakhstan.
National Tuberculosis Centre, Almaty, Kazakhstan.
Int J Tuberc Lung Dis. 2014 Mar;18(3):298-301. doi: 10.5588/ijtld.13.0558.
A total of 60 Mycobacterium tuberculosis isolates collected from patients in prisons in Kazakhstan and 125 from the civilian sector were examined using mycobacterial interspersed repetitive units-variable number of tandem repeat analysis in 2012. The proportion of tuberculosis strains with unique genotypes isolated from the civilian patients was 50.4%, while that in the prison patients was 31.7%. This difference was statistically significant (χ(2) 4.42, P 0.035), and may reflect a low genetic diversity of M. tuberculosis strains isolated from prison patients. The frequencies of mutations in the rpoB531 and katG315 genes of the M. tuberculosis strains isolated from the civilians and in the penitentiary system were not significantly different (rpoB531: 82.4% vs. 88.3%, and katG315: 98.4% vs. 100%, respectively).
2012年，对从哈萨克斯坦监狱患者中收集的60株结核分枝杆菌分离株以及从平民中收集的125株分离株，采用分枝杆菌散布重复单位-可变数目串联重复序列分析进行了检测。从平民患者中分离出的具有独特基因型的结核菌株比例为50.4%，而监狱患者中的这一比例为31.7%。这种差异具有统计学意义（χ(2)=4.42，P=0.035），可能反映了从监狱患者中分离出的结核分枝杆菌菌株的低遗传多样性。从平民和监狱系统中分离出的结核分枝杆菌菌株的rpoB531和katG315基因突变频率无显著差异（rpoB531分别为82.4%和88.3%，katG315分别为98.4%和100%）。
