Reis Ana Julia, David Simone Maria Martini de, Nunes Luciana de Souza, Valim Andreia Rosane de Moura, Possuelo Lia Gonçalves
Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brasil.
Laboratório Central do Estado do Rio Grande do Sul (IPB-LACEN/RS), Rio Grande do Sul, Brasil.
J Bras Pneumol. 2016 Jul-Aug;42(4):286-289. doi: 10.1590/S1806-37562016000000023.
We conducted a cross-sectional, retrospective study, characterized by classical and molecular epidemiology, involving M. tuberculosis isolates from a regional prison in southern Brazil. Between January of 2011 and August of 2014, 379 prisoners underwent sputum smear microscopy and culture; 53 (13.9%) were diagnosed with active tuberculosis. Of those, 8 (22.9%) presented with isoniazid-resistant tuberculosis. Strain genotyping was carried out by 15-locus mycobacterial interspersed repetitive unit-variable-number tandem-repeat analysis; 68.6% of the patients were distributed into five clusters, and 87.5% of the resistant cases were in the same cluster. The frequency of drug-resistant tuberculosis cases and the rate of recent transmission were high. Our data suggest the need to implement an effective tuberculosis control program within the prison system. RESUMO Estudo transversal, retrospectivo, com isolados de M. tuberculosis de pacientes de um presídio regional no sul do Brasil, caracterizado através de epidemiologia clássica e molecular. Entre janeiro de 2011 e agosto de 2014, 379 detentos foram submetidos a baciloscopia e cultura, sendo 53 (13,9%) diagnosticados com tuberculose ativa. Desses, 8 (22,9%) apresentavam tuberculose resistente a isoniazida. A genotipagem das cepas foi realizada por 15-locus mycobacterial interspersed repetitive units-variable number of tandem repeat analysis; 68,6% dos pacientes estavam distribuídos em cinco clusters, e 87,5% dos casos resistentes estavam em um mesmo cluster. Verificou-se uma frequência elevada de casos de resistência e alta taxa de transmissão recente. Estes dados sugerem a necessidade da implantação de um programa efetivo de controle da tuberculose no sistema prisional.
我们开展了一项横断面回顾性研究，采用经典和分子流行病学方法，研究对象为巴西南部某地区监狱的结核分枝杆菌分离株。2011年1月至2014年8月期间，379名囚犯接受了痰涂片显微镜检查和培养；53人（13.9%）被诊断为活动性结核病。其中，8人（22.9%）为耐异烟肼结核病。通过15位点分枝杆菌插入重复单元可变数目串联重复序列分析进行菌株基因分型；68.6%的患者被分为五个簇，87.5%的耐药病例在同一簇中。耐多药结核病病例的发生率和近期传播率都很高。我们的数据表明，需要在监狱系统内实施有效的结核病控制计划。摘要 对巴西南部某地区监狱患者的结核分枝杆菌分离株进行横断面回顾性研究，采用经典和分子流行病学方法。2011年1月至2014年8月期间，379名囚犯接受了痰涂片显微镜检查和培养，53人（13.9%）被诊断为活动性结核病。其中，8人（22.9%）为耐异烟肼结核病。通过15位点分枝杆菌插入重复单元可变数目串联重复序列分析进行菌株基因分型；68.6%的患者被分为五个簇，87.5%的耐药病例在同一簇中。耐药病例的发生率较高，近期传播率也较高。这些数据表明，需要在监狱系统内实施有效的结核病控制计划。
