Department of Population Health and Primary Care, Norwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK,
Curr Osteoporos Rep. 2014 Jun;12(2):205-10. doi: 10.1007/s11914-014-0212-5.
Osteoporosis and fragility fractures are a growing problem for our aging population with around 1 in 2 women and 1 in 5 men suffering from an osteoporotic fracture during their lifetime. Although there are established factors that can reduce the risk of fracture such as maintaining physical activity, ceasing smoking, and adequate vitamin D status, and intakes of calcium; dietary mechanisms are less well established. The relevance of the flavonoid group of bioactive compounds found in fruits and vegetables has been less investigated. Two human epidemiologic studies in women found positive associations between total dietary flavonoid intake and bone mineral density. Flavonoids may protect against bone loss by upregulating signaling pathways that promote osteoblast function, by reducing the effects of oxidative stress or chronic low-grade inflammation. The limitations of the existing research are explored in the manuscript and it is concluded that further research is needed, in this promising area.
骨质疏松症和脆性骨折是我们老龄化人口日益严重的问题，大约每 2 名女性和每 5 名男性中就有 1 人在其一生中会遭受骨质疏松性骨折。尽管有一些已确定的因素可以降低骨折风险，如保持身体活动、戒烟和充足的维生素 D 状态以及钙摄入；但饮食机制的相关性还不太明确。在水果和蔬菜中发现的类黄酮生物活性化合物的相关性研究较少。两项针对女性的人体流行病学研究发现，总膳食类黄酮摄入量与骨密度之间存在正相关关系。类黄酮可能通过上调促进成骨细胞功能的信号通路、减少氧化应激或慢性低度炎症的影响来防止骨质流失。本文探讨了现有研究的局限性，并得出结论，需要在这一有前途的领域进行进一步研究。
