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与骨质疏松症相关的营养素和膳食模式。

Nutrients and Dietary Patterns Related to Osteoporosis.

机构信息

Department of Endocrinology and Nutrition, Virgen de las Nieves Hospital, 18014 Granada, Spain.

Instituto de Investigación Biosanitaria (Ibs.GRANADA), 18014 Granada, Spain.

出版信息

Nutrients. 2020 Jul 3;12(7):1986. doi: 10.3390/nu12071986.

Abstract

Osteoporosis is a common chronic disease characterized by a decrease in bone mineral density, impaired bone strength, and an increased risk of fragility fractures. Fragility fractures are associated with significant morbidity, mortality and disability and are a major public health problem worldwide. The influence of nutritional factors on the development and progression of this disease can be significant and is not yet well established. Calcium intake and vitamin D status are considered to be essential for bone metabolism homeostasis. However, some recent studies have questioned the usefulness of calcium and vitamin D supplements in decreasing the risk of fractures. The adequate intake of protein, vegetables and other nutrients is also of interest, and recommendations have been established by expert consensus and clinical practice guidelines. It is important to understand the influence of nutrients not only in isolation but also in the context of a dietary pattern, which is a complex mixture of nutrients. In this review, we evaluate the available scientific evidence for the effects of the main dietary patterns on bone health. Although some dietary patterns seem to have beneficial effects, more studies are needed to fully elucidate the true influence of diet on bone fragility.

摘要

骨质疏松症是一种常见的慢性疾病,其特征是骨矿物质密度降低、骨强度受损以及脆性骨折的风险增加。脆性骨折与显著的发病率、死亡率和残疾有关,是全球范围内的一个主要公共卫生问题。营养因素对这种疾病的发展和进展的影响可能是显著的,但尚未得到充分证实。钙摄入和维生素 D 状态被认为对骨骼代谢平衡至关重要。然而,一些最近的研究质疑了钙和维生素 D 补充剂在降低骨折风险方面的有效性。蛋白质、蔬菜和其他营养素的充足摄入也受到关注,专家共识和临床实践指南已经制定了相关建议。了解营养素的影响不仅要孤立地进行,还要在饮食模式的背景下进行,因为饮食模式是一种复杂的营养素混合物。在这篇综述中,我们评估了主要饮食模式对骨骼健康的影响的现有科学证据。虽然一些饮食模式似乎有有益的影响,但需要更多的研究来充分阐明饮食对骨骼脆弱性的真正影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c3/7400143/5e951f68cbf3/nutrients-12-01986-g001.jpg

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