Tandon Vishal R, Sharma Sudhaa, Mahajan Annil, Mahajan Shagun
Department of Pharmacology and Therapeutic, Super-Specialty Hospital, Government Medical College, Jammu, Jammu and Kashmir, India.
Department of Obstetrics and Gynecology, Super-Specialty Hospital, Government Medical College, Jammu, Jammu and Kashmir, India.
J Midlife Health. 2014 Jan;5(1):23-8. doi: 10.4103/0976-7800.127787.
The aim of the following study is to evaluate the effect of life-style modification on postmenopausal (PM) overweight and obese Indian women in a randomized controlled 24 week study.
Two groups were formed Group I (n = 30) was designated as intervention (dietary and exercise group) and Group II (n = 24) served as control. Comparison of weight, waist circumference (WC) and body mass index (BMI) were made and compared among two groups at 4, 8, 16 and 24 weeks.
Mean age at menopause was 48.35 years versus 49.65 years; mean number of menopausal symptoms were 5.70 ± 1.76 versus 5.10 ± 1.56 and mean duration since menopause was 2.70 versus 2.90 years in Groups I and II respectively. When the effect of Group I and control on weight was compared at 4, 8, 16 and 24 weeks, there was no significant difference between them up to 8 week. At 8 weeks Group I caused a significant decrease in weight (P ≤ 0.05) when compared with control arm and which continued throughout the study period (P < 0.05) at both 16 and 24 weeks. Group I produced a significant reduction in WC from 8 weeks onwards up to 24 weeks (P ≤ 0.05). BMI was statistically significant in Group I and the effect started at 4(th) week (P ≤ 0.05) and the differences in BMI reduction were highly significant at 16(th) and 24(th) weeks (P ≤ 0.001).
The results of the present study strongly recommend the life-style management to be incorporated in daily style of postmenopausal women under controlled supervision.
以下研究的目的是在一项为期24周的随机对照研究中，评估生活方式改变对绝经后（PM）超重和肥胖印度女性的影响。
分为两组，第一组（n = 30）为干预组（饮食和运动组），第二组（n = 24）为对照组。在第4、8、16和24周对两组的体重、腰围（WC）和体重指数（BMI）进行比较。
第一组和第二组的平均绝经年龄分别为48.35岁和49.65岁；平均绝经症状数量分别为5.70±1.76和5.10±1.56，绝经后的平均持续时间分别为2.70年和2.90年。当比较第一组和对照组在第4、8、16和24周对体重的影响时，在8周之前两组之间没有显著差异。在第8周时，与对照组相比，第一组导致体重显著下降（P≤0.05），并且在整个研究期间（第16周和24周时P<0.05）持续下降。从第8周开始到第24周，第一组的腰围显著降低（P≤0.05）。第一组的BMI具有统计学意义，效果从第4周开始（P≤0.05），在第16周和第24周时BMI降低的差异非常显著（P≤0.001）。
本研究结果强烈建议在可控的监督下，将生活方式管理纳入绝经后女性的日常生活方式中。
