Mieczkowska J, Rutkowska E, Mosiewicz J, Mosiewicz B
Department of Internal Diseases, Medical University of Lublin, Lublin, Poland.
Department of Tourism and Recreation, University of Life Sciences in Lublin, Lublin, Poland.
Dis Markers. 2016;2016:7169531. doi: 10.1155/2016/7169531. Epub 2016 Dec 26.
Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well as all the processes taking part in maintenance of efficient homeostasis. Presentation of the correlation between exercise test results and MMP-8 (metalloproteinase-8) and TIMP-1 (tissue inhibitor of metalloproteinases-1) levels was attempted in this work. MMP-8 is a proteolytic enzyme taking part in progression of diseases related to process of ageing. 62 healthy women in postmenopausal period were qualified for the study (mean age: 54 ± 3.6). There was exercise test on the treadmill according to Bruce's protocol performed. MMP-8 and TIMP-1 serum levels were measured. There was statistically important correlation between increased level of MMP-8 and increased level of TIMP-1 with lower results of exercise test observed. The conducted study provides further biochemical arguments for prophylactic role of physical activity, which lowers the risk of noninfectious diseases, typical for middle adulthood, by influencing physical capacity.
作为生活方式一部分的体育活动是影响健康状况的重要因素。需要耐力的运动尤为重要。氧代谢是所有较长时间训练过程的重要组成部分，它对心血管和呼吸系统的功能以及参与维持有效体内平衡的所有过程都有影响。本研究试图展示运动测试结果与MMP-8（金属蛋白酶-8）和TIMP-1（金属蛋白酶组织抑制剂-1）水平之间的相关性。MMP-8是一种参与与衰老过程相关疾病进展的蛋白水解酶。62名绝经后健康女性被纳入该研究（平均年龄：54±3.6岁）。根据布鲁斯方案在跑步机上进行了运动测试。测量了MMP-8和TIMP-1的血清水平。观察到MMP-8水平升高与TIMP-1水平升高以及运动测试结果较低之间存在统计学上的显著相关性。所进行的研究为体育活动的预防作用提供了进一步的生化依据，体育活动通过影响身体能力降低了中年期典型的非传染性疾病风险。
