Posokhov Igor N, Kulikova Natalya N, Starchenkova Irina V, Grigoricheva Elena A, Evdokimov Vitaly V, Orlov Artemy V, Rogoza Anatoly N
Hemodynamic Laboratory Ltd, Nizhny Novgorod, Russia.
3rd Republican Hospital, Saransk, Russia.
Vasc Health Risk Manag. 2014 Mar 19;10:139-44. doi: 10.2147/VHRM.S58351. eCollection 2014.
Arterial stiffness, as measured by the pulse wave velocity (PWV), is recommended for routine use in clinical practice as an important parameter for the evaluation of cardiovascular risk.1 New 24-hour monitors (eg, with Vasotens technology; Petr Telegin Company, Nizhny Novgorod, Russian Federation) provide single PWV measurements as well as several PWV measurements over a period of 24 hours.2 Such 24-hour pulse wave analysis led to the development of the novel Pulse Time Index of Norm (PTIN), which is defined as the percentage of a 24-hour period during which the PWV does not exceed the 10 m/second PWV threshold. The aim of this study is to test the new PTIN for correlation with the left ventricular mass index (LVMI).
Oscillometrically generated waveform files (n=137) used for clinical research studies were reanalyzed using the new 2013 version of the Vasotens technology program, which enables PTIN calculations.
A good correlation (r=-0.72) between the PTIN and the LVMI was shown, which was significantly above the blood pressure load (r=0.41).
The PTIN generated by the Vasotens technology can be recommended as an indicator of end organ damage via hypertension.
脉搏波速度（PWV）所测量的动脉僵硬度，作为评估心血管风险的重要参数，被推荐用于临床实践的常规检测。新型24小时监测仪（例如采用Vasotens技术的监测仪；俄罗斯联邦下诺夫哥罗德的Petr Telegin公司）可提供单次PWV测量值以及24小时内的多次PWV测量值。这种24小时脉搏波分析促使了新型脉搏正常时间指数（PTIN）的产生，PTIN定义为24小时内PWV不超过10米/秒阈值的时间段所占的百分比。本研究的目的是测试新的PTIN与左心室质量指数（LVMI）的相关性。
使用能够进行PTIN计算的2013版Vasotens技术程序，重新分析用于临床研究的示波法生成的波形文件（n = 137）。
PTIN与LVMI之间呈现出良好的相关性（r = -0.72），这一相关性显著高于血压负荷（r = 0.41）。
Vasotens技术生成的PTIN可被推荐作为高血压所致终末器官损害的一个指标。
