Wang Yuan, Liu Zhi-Cheng, Xu Bin
Zhongguo Zhen Jiu. 2014 Jan;34(1):21-4.
To evaluate the efficacy and the relevant effect factors of acupuncture for type 2 diabetes mellitus (T2DM) in females.
Of 83 female patients of T2DM, 49 cases were deficiency of kidney yin syndrome and 34 cases were yin and yang deficiency syndrome. Acupuncture was adopted and the acupoints were selected according to the syndrome differentiation. In kidney yin deficiency syndrome, Taixi (KI 3), Shenmen (HT 7), Taichong (LR 3) and Sanyinjiao (SP 6), etc. were selected. In yin and yang deficiency syndrome, Shenshu (BL 23), Pishu (BL 20), Yishu (Extra) and Jingmen (GB 25), etc. were selected. In 3 courses of treatment, the changes in fasting plasma glucose (FPG), fasting insulin (FINS), insulin sensitivity index (ISI), insulin resistace index (Homa-IR), index of islet beta-cell function (Homa-beta), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were compared before and after treatment between the two groups. The relationship of the efficacy was analyzed in terms of the syndrome differentiation, age, duration of sickness, obesity and hereditary factors.
After the treatment, the levels of FPG, FINS, Homa-IR, TC, TG and LDL-C were reduced obviously (all P < 0.01) and the levels of ISI, Homa-beta and HDL-C were increased apparently (all P < 0.01). The total clinical effective rate was 80.7% (67/83), in which, that of kidney yin deficiency syndrome was 83.7% (41/49) and that of yin and yang deficiency syndrome was 76.5% (26/34). The efficacy was not different significantly between the two syndromes. But, the younger the age was, the better the efficacy was.
Acupuncture positively regulates the glucose and lipid metabolism in the patients of T2DM. This therapy improves insulin resistance, enhances the body sensitivity to insulin and improves insulin beta-cell function. The efficacy is related to the patient's age.
评估针刺治疗女性2型糖尿病（T2DM）的疗效及相关影响因素。
83例女性T2DM患者中，肾阴虚证49例，阴阳两虚证34例。采用针刺治疗，根据辨证选穴。肾阴虚证选取太溪（KI 3）、神门（HT 7）、太冲（LR 3）、三阴交（SP 6）等；阴阳两虚证选取肾俞（BL 23）、脾俞（BL 20）、胰俞（Extra）、京门（GB 25）等。治疗3个疗程，比较两组治疗前后空腹血糖（FPG）、空腹胰岛素（FINS）、胰岛素敏感指数（ISI）、胰岛素抵抗指数（Homa-IR）、胰岛β细胞功能指数（Homa-β）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的变化。从辨证、年龄、病程、肥胖及遗传因素等方面分析疗效的关系。
治疗后，FPG、FINS、Homa-IR、TC、TG和LDL-C水平明显降低（均P < 0.01），ISI、Homa-β和HDL-C水平明显升高（均P < 0.01）。总临床有效率为80.7%（67/83），其中肾阴虚证有效率为83.7%（41/49），阴阳两虚证有效率为76.5%（26/34）。两证型疗效差异无统计学意义。但年龄越小，疗效越好。
针刺对T2DM患者的糖脂代谢有积极的调节作用。该疗法可改善胰岛素抵抗，增强机体对胰岛素的敏感性，改善胰岛素β细胞功能。疗效与患者年龄有关。
