Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
ACS Appl Mater Interfaces. 2014 Apr 9;6(7):4935-9. doi: 10.1021/am5014858. Epub 2014 Mar 27.
Bioactive nanoparticles with controllable size and good colloidal stability were synthesized through surface modification of colloidal silica nanoparticles with Ca(OH)2 as the modifier. These modified nanoparticles showed good bioactivity, showing evidence of hydroxyapatite formation when incubated in simulated body fluid within 3 days. Comparison of bioactivity was made among different sized particles from nanoscale to microscale. It was found the bioactivity of these calcium modified colloidal silica particles generally decreased with particle size in the explored size range (40 nm particles showed bioactivity within 1 day). These particles were also found to be noncytotoxic but promote preosteoblast growth, thus making them promising bioactive additives for bone repair materials.
通过用 Ca(OH)2 作为改性剂对胶体硅纳米粒子进行表面改性，合成了具有可控尺寸和良好胶体稳定性的生物活性纳米粒子。这些改性纳米粒子表现出良好的生物活性，在模拟体液中孵育 3 天内显示出形成羟基磷灰石的证据。对不同尺寸（从纳米级到微级）的纳米粒子的生物活性进行了比较。结果发现，在所研究的尺寸范围内（40nm 粒子在 1 天内表现出生物活性），这些钙改性胶体硅粒子的生物活性通常随粒径的增大而降低。还发现这些粒子无细胞毒性，但能促进前成骨细胞生长，因此它们有望成为骨修复材料的生物活性添加剂。
