EP1, Soft Matter and Biological Physics Group, University of Augsburg, 86159 Augsburg, Germany; Nanosystems Initiative Munich (NIM), Schellingstraße 4, 80799 München, Germany.
EP1, Soft Matter and Biological Physics Group, University of Augsburg, 86159 Augsburg, Germany; Nanosystems Initiative Munich (NIM), Schellingstraße 4, 80799 München, Germany; Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
Adv Colloid Interface Sci. 2014 Jun;208:161-76. doi: 10.1016/j.cis.2014.03.002. Epub 2014 Mar 12.
Hydrodynamic lift forces acting on cells and particles in fluid flow receive ongoing attention from medicine, mathematics, physics and engineering. The early findings of Fåhræus & Lindqvist on the viscosity change of blood with the diameter of capillaries motivated extensive studies both experimentally and theoretically to illuminate the underlying physics. We review this historical development that led to the discovery of the inertial and non-inertial lift forces and elucidate the origins of these forces that are still not entirely clear. Exploiting microfluidic techniques induced a tremendous amount of new insights especially into the more complex interactions between the flow field and deformable objects like vesicles or red blood cells. We trace the way from the investigation of single cell dynamics to the recent developments of microfluidic techniques for particle and cell sorting using hydrodynamic forces. Such continuous and label-free on-chip cell sorting devices promise to revolutionize medical analyses for personalized point-of-care diagnosis. We present the state-of-the-art of different hydrodynamic lift-based techniques and discuss their advantages and limitations.
在医学、数学、物理和工程领域，流体流动中作用于细胞和颗粒的流体动力升力一直受到关注。Fåhræus 和 Lindqvist 早期关于毛细血管直径与血液粘度变化的发现，激发了广泛的实验和理论研究，以阐明潜在的物理机制。我们回顾了这一历史发展过程，发现了惯性和非惯性升力，并阐明了这些力的起源，这些力仍不完全清楚。利用微流控技术，特别是在研究流场与变形物体（如囊泡或红细胞）之间的更复杂相互作用方面，产生了大量新的见解。我们追溯了从单个细胞动力学研究到利用流体动力进行粒子和细胞分选的微流控技术的最新发展。这种连续且无需标记的片上细胞分选装置有望彻底改变个性化即时诊断的医学分析。我们展示了不同基于流体动力升力的技术的最新进展，并讨论了它们的优缺点。
