Laboratory for Affective Neuroscience, University of Wisconsin-Madison, Madison, WI 53706, USA.
Psychol Sci. 2009 Dec;20(12):1500-6. doi: 10.1111/j.1467-9280.2009.02476.x. Epub 2009 Nov 9.
Individuals show marked variation in their responses to threat. Such individual differences in behavioral inhibition play a profound role in mental and physical well-being. Behavioral inhibition is thought to reflect variation in the sensitivity of a distributed neural system responsible for generating anxiety and organizing defensive responses to threat and punishment. Although progress has been made in identifying the key constituents of this behavioral inhibition system in humans, the involvement of dorsolateral prefrontal cortex (DLPFC) remains unclear. Here, we acquired self-reported Behavioral Inhibition System Sensitivity scores and high-resolution electroencephalography from a large sample (n= 51). Using the enhanced spatial resolution afforded by source modeling techniques, we show that individuals with greater tonic (resting) activity in right-posterior DLPFC rate themselves as more behaviorally inhibited. This observation provides novel support for recent conceptualizations of behavioral inhibition and clues to the mechanisms that might underlie variation in threat-induced negative affect.
个体对威胁的反应存在明显差异。这种行为抑制的个体差异在心理和身体健康方面起着深远的作用。行为抑制被认为反映了负责产生焦虑和组织对威胁和惩罚的防御反应的分布式神经系统敏感性的变化。尽管在确定人类行为抑制系统的关键成分方面已经取得了进展，但背外侧前额叶皮层（DLPFC）的参与仍不清楚。在这里，我们从一个大样本（n=51）中获得了自我报告的行为抑制系统敏感性评分和高分辨率脑电图。利用源建模技术提供的增强空间分辨率，我们表明，右侧后 DLPFC 静息活动较大的个体将自己评为行为抑制程度更高。这一观察结果为行为抑制的最新概念化提供了新的支持，并为可能导致威胁引起的负面情绪变化的机制提供了线索。
