解锁宝库：从基因到精神分裂症生物学。
Unlocking the treasure trove: from genes to schizophrenia biology.
机构信息
*To whom correspondence should be addressed; Department of Psychiatry & Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland; tel: +353-1-8962467, fax: +353-1-8963405, e-mail:
出版信息
Schizophr Bull. 2014 May;40(3):492-6. doi: 10.1093/schbul/sbu042. Epub 2014 Mar 27.
Abstract
Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function in model systems. The confluence of these two research fields--gene discovery and functional biology--may offer novel insights into schizophrenia etiology. We review recent advances in these fields, consider the likely obstacles to progress, and consider strategies as to how these can be overcome.
摘要
在确定精神分裂症的遗传病因方面正在取得重大进展。随着涉及的基因列表不断增加，基因编辑技术的平行发展为在模型系统中研究基因功能提供了新方法。这两个研究领域——基因发现和功能生物学的融合——可能为精神分裂症病因提供新的见解。我们回顾了这些领域的最新进展，考虑了可能存在的进展障碍，并考虑了如何克服这些障碍的策略。
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