植物基因组工程全面展开。
Plant genome engineering in full bloom.
机构信息
Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, CA 92521, USA; Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, CA 92521, USA; Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
出版信息
Trends Plant Sci. 2014 May;19(5):284-7. doi: 10.1016/j.tplants.2014.02.014. Epub 2014 Mar 24.
The recent development of tools for precise editing of user-specified sequences is rapidly changing the landscape for plant genetics and biotechnology. It is now possible to target mutations and regulatory proteins to specific sites in a genome using zinc-finger nucleases (ZFNs), transcription activator-like endonucleases (TALENs), or the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system. Here we provide an update of recent developments in CRISPR/Cas9 technology and highlight online resources that will help biologists adopt new genome-editing tools.
最近用于精确编辑用户指定序列的工具的发展正在迅速改变植物遗传学和生物技术的格局。现在，使用锌指核酸酶（ZFNs）、转录激活样效应物核酸酶（TALENs）或成簇规律间隔短回文重复序列（CRISPR）/CRISPR 相关蛋白 9（Cas9）系统，就可以将突变和调节蛋白靶向到基因组中的特定位置。本文提供了 CRISPR/Cas9 技术的最新进展，并重点介绍了在线资源，这些资源将帮助生物学家采用新的基因组编辑工具。
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