在马来西亚发现的一种涉及CRF01_AE、B亚型和B'亚型的复杂HIV-1独特重组形式的基因组序列。
Genome Sequence of a Complex HIV-1 Unique Recombinant Form Involving CRF01_AE, Subtype B, and Subtype B' Identified in Malaysia.
作者信息
Chow Wei Zhen, Nizam Sarimie, Ong Lai Yee, Ng Kim Tien, Chan Kok Gan, Takebe Yutaka, Koh Clayton, Kamarulzaman Adeeba, Tee Kok Keng
机构信息
Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
Genome Announc. 2014 Mar 27;2(2):e00139-14. doi: 10.1128/genomeA.00139-14.
Abstract
A complex HIV-1 unique recombinant form involving subtypes CRF01_AE, B, and B' was recently identified from an injecting drug user in Malaysia. A total of 13 recombination breakpoints were mapped across the near-full-length genome of isolate 10MYPR226, indicating the increasingly diverse molecular epidemiology and frequent linkage among various high-risk groups.
摘要
最近在马来西亚一名注射吸毒者中发现了一种涉及CRF01_AE、B和B'亚型的复杂HIV-1独特重组形式。在分离株10MYPR226的近全长基因组中总共定位了13个重组断点，这表明分子流行病学日益多样化，以及不同高危人群之间频繁的联系。
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