Haffejee I E
R.K. Khan Hospital, Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Durban, South Africa.
Ann Trop Paediatr. 1988 Dec;8(4):225-9. doi: 10.1080/02724936.1988.11748576.
In a prospective, controlled, randomized single-blind clinical trial, treatment with cefotaxime (CTX) was compared with that with standard therapy (ST), which consisted of a penicillin-chloramphenicol combination with or without sulphadiazine, in 31 patients (excluding neonates) with proven bacterial meningitis. The two groups of patients were comparable in age, sex, clinical presentation and causative pathogens. The case fatality rate was 12.5% for the CTX group and 20% for the ST group, but this difference was not significant. The times taken for the cerebrospinal fluid (CSF) to become sterile and the temperature to normalize, the mean duration of treatment, complications and adverse effects were similar for the two regimens. Neurological or developmental abnormalities on follow-up were not significantly different for the two groups. It is concluded that CTX is a suitable alternative for treatment of bacterial meningitis in infants and children.
在一项前瞻性、对照、随机单盲临床试验中，对31例（不包括新生儿）确诊为细菌性脑膜炎的患者，将头孢噻肟（CTX）治疗与标准疗法（ST）进行了比较，标准疗法包括青霉素 - 氯霉素联合用药，可加用或不加用磺胺嘧啶。两组患者在年龄、性别、临床表现和致病病原体方面具有可比性。CTX组的病死率为12.5%，ST组为20%，但差异无统计学意义。两种治疗方案使脑脊液（CSF）转为无菌状态的时间、体温恢复正常的时间、平均治疗持续时间、并发症及不良反应相似。两组随访时的神经或发育异常情况无显著差异。结论是CTX是治疗婴幼儿细菌性脑膜炎的合适替代药物。
