一种糖基转移酶催化的氨基糖核苷酸合成的简单策略。
A simple strategy for glycosyltransferase-catalyzed aminosugar nucleotide synthesis.
出版信息
Chembiochem. 2014 Mar 21;15(5):647-52. doi: 10.1002/cbic.201300779.
Abstract
A set of 2-chloro-4-nitrophenyl glucosamino-/xylosaminosides were synthesized and assessed as potential substrates in the context of glycosyltransferase-catalyzed formation of the corresponding UDP/TDP-α-D-glucosamino-/xylosaminosugars and in single-vessel model transglycosylation reactions. This study highlights a robust platform for aminosugar nucleotide synthesis and reveals OleD Loki to be a proficient catalyst for U/TDP-aminosugar synthesis and utilization
摘要
合成了一组 2-氯-4-硝基苯氨基葡萄糖基-/木糖苷，并将其评估为糖基转移酶催化形成相应的 UDP/TDP-α-D-氨基葡萄糖基-/木糖苷以及单血管模型转糖基化反应中的潜在底物。本研究突出了一种用于氨基糖核苷酸合成的强大平台，并揭示了 OleD Loki 是 U/TDP-氨基糖合成和利用的高效催化剂。
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