Ali Omar, Cerjak Diana, Kent Jack W, James Roland, Blangero John, Zhang Yi
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Pediatr Obes. 2014 Jun;9(3):e58-e62. doi: 10.1111/j.2047-6310.2014.218.x. Epub 2014 Mar 27.
The objective of this study was to assess genetic and phenotypic correlations of obesity-related cardiometabolic risk factors in a family-based cohort.
Anthropometric, body composition and biochemical measurements were collected on 999 members of 111 extended Midwestern US families of Northern European origin. Forward stepwise regression was used to identify which of Tanner stage, sex, Tanner stage by sex, body fat mass index, body fat percentage (dual-energy X-ray absorptiometry), visceral fat (VF)/subcutaneous fat (SubQF) (computed tomography scans for adults or magnetic resonance imaging for children), VF, SubQF, body mass index (BMI)% and waist to height ratio most influence homeostasis model assessment (HOMA), high-density lipoprotein cholesterol (HDL-c), plasma triglycerides (TG) and low-density lipoprotein cholesterol (LDL-c).
In children and adolescents, subcutaneous adiposity was the most significant covariate for HOMA (P < 0.001) and TG (P = 0.001), and BMI percentile for HDL-c (P = 0.002) and LDL-c (P < 0.001). In adults, waist-height ratio (P < 0.001), VF/SubQF ratio (P = 0.001) and BMI (P = 0.02) were most significant for HOMA; VF (P < 0.001) and BMI (P = 0.02) for TG and VF for LDL-c (P = 0.001).
Subcutaneous adiposity at the waist is a more significant predictor of metabolic syndrome traits in children and adolescents than it is in adults.
本研究的目的是评估一个基于家庭的队列中肥胖相关心脏代谢危险因素的遗传和表型相关性。
收集了来自美国中西部111个北欧裔大家庭的999名成员的人体测量、身体成分和生化指标。采用向前逐步回归来确定以下因素中哪些对稳态模型评估（HOMA）、高密度脂蛋白胆固醇（HDL-c）、血浆甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-c）影响最大：坦纳分期、性别、性别与坦纳分期的交互项、体脂质量指数、体脂百分比（双能X线吸收法）、内脏脂肪（VF）/皮下脂肪（SubQF）（成人采用计算机断层扫描，儿童采用磁共振成像）、VF、SubQF、体重指数（BMI）百分位数和腰高比。
在儿童和青少年中，皮下脂肪过多是HOMA（P＜0.001）和TG（P = 0.001）的最显著协变量，BMI百分位数是HDL-c（P = 0.002）和LDL-c（P＜0.001）的最显著协变量。在成年人中，腰高比（P＜0.001）、VF/SubQF比值（P = 0.001）和BMI（P = 0.02）对HOMA影响最大；VF（P＜0.001）和BMI（P = 0.02）对TG影响最大，VF对LDL-c影响最大（P = 0.001）。
与成年人相比，儿童和青少年腰部的皮下脂肪过多是代谢综合征特征更显著的预测指标。
