Shailaja V V, Reddy Ashok Kumar, Alimelu M, Sadanand L N R
Department of Microbiology, Niloufer Hospital for Women and Children, Hyderabad 500004, India.
GHR Micro Diagnostics, Hyderabad 500082, India.
Int J Pediatr. 2014;2014:918907. doi: 10.1155/2014/918907. Epub 2014 Feb 9.
Clinical and microbiological profile of 9 neonates with meningitis by Elizabethkingia meningosepticum identified by 16S ribosomal gene sequencing was studied. All the clinical isolates were resistant to cephalosporins, aminoglycosides, trimethoprim-sulfamethoxazole, β -lactam combinations, carbapenems and only one isolate was susceptible to ciprofloxacin. All the isolates were susceptible to vancomycin. Six of nine neonates died even after using vancomycin, based on susceptibility results. E. meningosepticum meningitis in neonates results in high mortality rate. Though the organism is susceptible to vancomycin in vitro, its efficacy in vivo is questionable and it is difficult to determine the most appropriate antibiotic for treating E. meningosepticum meningitis in neonates.
对通过16S核糖体基因测序鉴定出的9例由脑膜败血伊丽莎白金菌引起脑膜炎的新生儿的临床和微生物学特征进行了研究。所有临床分离株对头孢菌素、氨基糖苷类、甲氧苄啶-磺胺甲恶唑、β-内酰胺组合、碳青霉烯类均耐药，只有1株分离株对环丙沙星敏感。所有分离株对万古霉素敏感。根据药敏结果，9例新生儿中有6例即使使用了万古霉素仍死亡。新生儿脑膜败血伊丽莎白金菌脑膜炎导致高死亡率。尽管该菌在体外对万古霉素敏感，但其体内疗效存疑，且难以确定治疗新生儿脑膜败血伊丽莎白金菌脑膜炎的最合适抗生素。
