Georgiou-Karistianis Nellie, Long Jeffrey D, Lourens Spencer G, Stout Julie C, Mills James A, Paulsen Jane S
School of Psychological Sciences, Monash University , Wellington Road, Clayton, Victoria , Australia.
World J Biol Psychiatry. 2014 Aug;15(6):459-71. doi: 10.3109/15622975.2014.895042. Epub 2014 Mar 28.
To examine longitudinal changes in movement sequencing in prodromal Huntington's disease (HD) participants (795 prodromal HD; 225 controls) from the PREDICT-HD study.
Prodromal HD participants were tested over seven annual visits and were stratified into three groups (low, medium, high) based on their CAG-Age Product (CAP) score, which indicates likely increasing proximity to diagnosis. A cued movement sequence task assessed the impact of advance cueing on response initiation and execution via three levels of advance information.
Compared to controls, all CAP groups showed longer initiation and movement times across all conditions at baseline, demonstrating a disease gradient for the majority of outcomes. Across all conditions, the high CAP group had the highest mean for baseline testing, but also demonstrated an increase in movement time across the study. For initiation time, the high CAP group showed the highest mean baseline time across all conditions, but also faster decreasing rates of change over time.
With progress to diagnosis, participants may increasingly use compensatory strategies, as evidenced by faster initiation. However, this occurred in conjunction with slowed execution times, suggesting a decline in effectively accessing control processes required to translate movement into effective execution.
通过PREDICT-HD研究，考察前驱期亨廷顿舞蹈病（HD）参与者（795名前驱期HD患者；225名对照者）运动序列的纵向变化。
前驱期HD参与者接受了为期七年的年度测试，并根据其CAG-年龄乘积（CAP）得分分为三组（低、中、高），该得分表明其接近诊断的可能性增加。一项提示运动序列任务通过三个层次的提前信息评估了提前提示对反应启动和执行的影响。
与对照组相比，所有CAP组在基线时所有条件下的启动时间和运动时间都更长，这表明大多数结果存在疾病梯度。在所有条件下，高CAP组在基线测试中的平均值最高，但在整个研究过程中运动时间也有所增加。对于启动时间，高CAP组在所有条件下的平均基线时间最高，但随着时间的推移变化率下降也更快。
随着接近诊断，参与者可能越来越多地使用补偿策略，启动更快证明了这一点。然而，这与执行时间减慢同时发生，表明在将运动转化为有效执行所需的控制过程的有效利用方面有所下降。
