Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge MA 02138, USA.
Cell. 2014 Mar 27;157(1):41-50. doi: 10.1016/j.cell.2014.02.013.
No metazoan cell survives on its own, absent the signals and support of its milieu. For multicellular life with specialized tissues to persist, organization is everything and so defining the association of position with cell state is critical to understanding how tissues function, maintain, and repair. This review focuses specifically on place for progenitor and stem cells. Especially emphasized are hematopoietic cells that balance free movement and stable position and where concepts of regulatory interrelationships have been shown with some precision. It reviews classical and emerging concepts of the niche, particularly considering how niche functions may participate in neoplastic disease.
没有后生动物细胞能在没有其环境中的信号和支持的情况下独自存活。对于具有专门组织的多细胞生命的持续存在，组织是一切，因此，定义位置与细胞状态的关联对于理解组织如何发挥功能、维持和修复至关重要。本综述特别关注祖细胞和干细胞的位置。特别强调的是血液细胞，它们平衡自由运动和稳定位置，并且已经以一定的精度展示了调节相互关系的概念。它回顾了小生境的经典和新兴概念，特别是考虑了小生境功能如何参与肿瘤疾病。
