Department of Pathology and Laboratory MedicineUniversity of Rochester School of Medicine, Rochester, New York 14642, USA.
Stem Cells. 2013 Jun;31(6):1044-50. doi: 10.1002/stem.1370.
Hematopoietic stem cell (HSC) behavior is governed in large part by interactions of the blood system with the bone microenvironment. Increasing evidence demonstrates the profound role the local HSC microenvironment or niche plays in normal stem cell function, in therapeutic activation and in the setting of malignancy. A number of cellular and molecular components of the microenvironment have been identified thus far, several of which are likely to provide exciting therapeutic targets in the near future. Clinically effective strategies for niche manipulation, however, require careful study of the interaction of these niche components. Some of the key findings defining these regulatory interactions are explored in this concise review, with special emphasis on potential translational applications.
造血干细胞（HSC）的行为在很大程度上受到血液系统与骨骼微环境相互作用的控制。越来越多的证据表明，局部 HSC 微环境或龛在正常干细胞功能、治疗性激活以及恶性肿瘤发生中起着深远的作用。迄今为止，已经确定了微环境的许多细胞和分子成分，其中一些可能在不久的将来为治疗提供有吸引力的靶点。然而，临床有效的龛位操作策略需要仔细研究这些龛位成分的相互作用。本综述探讨了其中一些定义这些调节相互作用的关键发现，并特别强调了潜在的转化应用。
