G 蛋白偶联受体沿着内吞途径的信号转导。
GPCR signaling along the endocytic pathway.
机构信息
Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA.
Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA.
出版信息
Curr Opin Cell Biol. 2014 Apr;27:109-16. doi: 10.1016/j.ceb.2013.10.003. Epub 2013 Dec 28.
Abstract
Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.
摘要
许多 G 蛋白偶联受体（GPCR）在激动剂诱导激活后会内吞。虽然内吞作用长期以来一直与细胞反应性的体内稳态衰减有关，但来自广泛真核生物研究的积累证据表明，内吞途径也有助于产生受体引发的信号本身。在这里，我们回顾了这一领域的最新进展，主要讨论但不限于哺乳动物细胞中的 GPCR 信号转导。
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