铑催化的偶氮苯与磺酰叠氮的直接 C-H 酰胺化反应：一种合成空间位阻邻位取代的芳香族偶氮化合物的方法。
Rhodium-catalyzed direct C-H amidation of azobenzenes with sulfonyl azides: a synthetic route to sterically hindered ortho-substituted aromatic azo compounds.
机构信息
School of Chemical and Material Science, Shanxi Normal University , Linfen, 041004, China.
出版信息
J Org Chem. 2014 May 2;79(9):4180-5. doi: 10.1021/jo500372d. Epub 2014 Apr 11.
PMID:24684665
Abstract
A rhodium(III)-catalyzed direct ortho-amidation of azobenzenes with sulfonyl azides as the amino source is disclosed. This reaction exhibits a broad substrate scope, high functional group tolerance, and regioselectivity, providing a variety of sterically hindered ortho-substituted azobenzene derivatives in good to excellent yield.
摘要
本文公开了一种铑(III)催化的芳基重氮盐与磺酰叠氮作为氨基源的直接邻位酰胺化反应。该反应具有广泛的底物范围、高官能团容忍度和区域选择性，能够以良好至优秀的收率得到多种位阻较大的邻位取代的偶氮苯衍生物。
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