Javed Fawad, Samaranayake Lakshman P, Romanos Georgios E
Research Associate, Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Laboratory, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Photochem Photobiol Sci. 2014 May;13(5):726-34. doi: 10.1039/c3pp50426c.
The aim was to review the efficacy of antimicrobial photodynamic therapy (PDT) in the treatment of oral fungal infections. To address the focused question "Should PDT be considered a possible treatment regimen for oral fungal infections?" PubMed/Medline and Google-Scholar databases were searched from 1997 up to March 2014 using various combinations of the following key words: "Candida albicans"; "Candidiasis"; "Candidosis"; "denture stomatitis"; "oral" and "photodynamic therapy". Original studies, experimental studies and articles published solely in English language were sought. Letters to the editor, historic reviews and unpublished data were excluded. Pattern of the present literature review was customized to mainly summarize the pertinent information. Fifteen studies (3 clinical and 12 experimental) were included. All studies reported antimicrobial PDT to be an effective antifungal treatment strategy. One study reported PDT and azole therapy to be equally effective in the treatment of oral fungal infections. Methylene blue, toluidine blue and porphyrin derivative were the most commonly used photosensitizers. The laser wavelengths and power output ranged between ∼455 nm-660 nm and 30 mW-400 mW. The energy fluence ranged between 26-245 J cm(-2) and the duration or irradiation ranged between 10 seconds and 26 minutes. Clinical effectiveness of antimicrobial PDT as a potent therapeutic strategy for oral fungal infections requires further investigations.
本研究旨在回顾抗菌光动力疗法（PDT）治疗口腔真菌感染的疗效。为回答“PDT是否应被视为口腔真菌感染的一种可能治疗方案？”这一核心问题，我们于1997年至2014年3月期间，使用以下关键词的不同组合在PubMed/Medline和谷歌学术数据库中进行了检索：“白色念珠菌”；“念珠菌病”；“假丝酵母菌病”；“义齿性口炎”；“口腔”以及“光动力疗法”。我们检索了仅以英文发表的原始研究、实验研究及文章。排除了致编辑信、历史综述及未发表的数据。本次文献综述的模式经过定制，主要用于总结相关信息。共纳入15项研究（3项临床研究和12项实验研究）。所有研究均报告抗菌PDT是一种有效的抗真菌治疗策略。一项研究报告称，PDT和唑类疗法在治疗口腔真菌感染方面同样有效。亚甲蓝、甲苯胺蓝和卟啉衍生物是最常用的光敏剂。激光波长和功率输出范围分别为~455 nm - 660 nm和30 mW - 400 mW。能量通量范围为26 - 245 J cm(-2)，照射持续时间范围为10秒至26分钟。抗菌PDT作为口腔真菌感染的一种有效治疗策略的临床有效性仍需进一步研究。
