Department of Oral Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Pediatric Otolaryngology, Head and Neck Surgery, Chair of Pediatric Surgery, Medical University of Silesia, 40-752 Katowice, Poland.
Int J Mol Sci. 2024 Jul 26;25(15):8136. doi: 10.3390/ijms25158136.
Oral candidiasis is a common problem among immunocompetent patients. The frequent resistance of strains to popular antimycotics makes it necessary to look for alternative methods of treatment. The authors conducted a systematic review following the PRISMA 2020 guidelines. The objective of this review was to determine if curcumin-mediated blue light could be considered as an alternative treatment for oral candidiasis. PubMed, Google Scholar, and Cochrane Library databases were searched using a combination of the following keywords: ( OR candidiasis oral OR candidiasis oral OR denture stomatitis) AND (curcumin OR photodynamic therapy OR apt OR photodynamic antimicrobial chemotherapy OR PACT OR photodynamic inactivation OR PDI). The review included in vitro laboratory studies with spp., in vivo animal studies, and randomized control trials (RCTs) involving patients with oral candidiasis or prosthetic stomatitis, published only in English. The method of elimination of species in the studies was curcumin-mediated aPDT. A total of 757 studies were identified. Following the analysis of the titles and abstracts of the studies, only 42 studies were selected for in-depth screening, after which 26 were included in this study. All studies evaluated the antifungal efficacy of curcumin-mediated aPDT against and non-. In studies conducted with planktonic cells solutions, seven studies demonstrated complete elimination of spp. cells. The remaining studies demonstrated only partial elimination. In all cases, experiments on single-species yeast biofilms demonstrated partial, statistically significant inhibition of cell growth and reduction in biofilm mass. In vivo, curcumin-mediated aPDT has shown good antifungal activity against oral candidiasis also in an animal model. However, its clinical efficacy as a potent therapeutic strategy for oral candidiasis requires few further RCTs.
口腔念珠菌病是免疫功能正常患者的常见问题。由于菌株对常用抗真菌药物的频繁耐药，有必要寻找替代治疗方法。作者按照 PRISMA 2020 指南进行了系统评价。本综述的目的是确定姜黄素介导的蓝光是否可被视为口腔念珠菌病的一种替代治疗方法。使用以下关键词的组合在 PubMed、Google Scholar 和 Cochrane Library 数据库中进行了搜索：(OR candidiasis oral OR candidiasis oral OR denture stomatitis) AND (curcumin OR photodynamic therapy OR apt OR photodynamic antimicrobial chemotherapy OR PACT OR photodynamic inactivation OR PDI)。本综述纳入了使用姜黄素介导的 aPDT 消除 spp. 的体外实验室研究、体内动物研究和涉及口腔念珠菌病或义齿性口炎患者的随机对照试验（RCT），且仅纳入以英文发表的研究。研究中消除物种的方法为姜黄素介导的 aPDT。共确定了 757 项研究。在分析研究的标题和摘要后，仅选择了 42 项进行深入筛选，其中 26 项纳入本研究。所有研究均评估了姜黄素介导的 aPDT 对 和 非-的抗真菌疗效。在进行浮游细胞溶液的研究中，有 7 项研究显示完全消除了 spp. 细胞。其余研究显示仅部分消除。在所有情况下，针对单种酵母生物膜的实验均显示细胞生长的部分、统计学上显著抑制和生物膜质量减少。在体内，姜黄素介导的 aPDT 在动物模型中也显示出对口腔念珠菌病的良好抗真菌活性。然而，其作为治疗口腔念珠菌病的有效治疗策略的临床疗效还需要进行少数进一步的 RCT。
