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光动力疗法在感染性口腔疾病治疗中的潜力。

Potential of photodynamic therapy in the management of infectious oral diseases.

作者信息

Casu Cinzia, Orrù Germano

机构信息

Department of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Cagliari 09124, Italy.

出版信息

World J Exp Med. 2024 Mar 20;14(1):84284. doi: 10.5493/wjem.v14.i1.84284.

Abstract

Photodynamic therapy (PDT) can take place in the presence of three elements: Light with an appropriate wavelength; a photosensitizer; and the presence of oxygen. This type of treatment is very effective overall against bacterial, viral and mycotic cells. In the last 10 years many papers have been published on PDT with different types of photosensitizers (, methylene blue, toluidine blue, indocyanine green, curcumin-based photosensitizers), different wavelengths (, 460 nm, 630 nm, 660 nm, 810 nm) and various parameters (, power of the light, time of illumination, number of sessions). In the scientific literature all types of PDT seem very effective, even if it is difficult to find a standard protocol for each oral pathology. PDT could be an interesting way to treat some dangerous oral infections refractory to common pharmacological therapies, such as candidiasis from multidrug-resistant .

摘要

光动力疗法(PDT)的发生需要具备三个要素:适当波长的光;一种光敏剂;以及氧气的存在。总体而言,这种治疗方法对细菌、病毒和真菌细胞非常有效。在过去十年中,已经发表了许多关于光动力疗法的论文,涉及不同类型的光敏剂(如亚甲蓝、甲苯胺蓝、吲哚菁绿、基于姜黄素的光敏剂)、不同波长(如460纳米、630纳米、660纳米、810纳米)以及各种参数(如光功率、光照时间、疗程次数)。在科学文献中,所有类型的光动力疗法似乎都非常有效,尽管很难为每种口腔病理学找到一个标准方案。光动力疗法可能是治疗一些对常规药物治疗难治的危险口腔感染的有趣方法,例如耐多药念珠菌病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/10999068/8a86009e81ce/84284-g001.jpg

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