Dorella Fernanda A, Gala-Garcia Alfonso, Pinto Anne C, Sarrouh Boutros, Antunes Camila A, Ribeiro Dayana, Aburjaile Flavia F, Fiaux Karina K, Guimarães Luis C, Seyffert Núbia, El-Aouar Rachid A, Silva Renata, Hassan Syed S, Castro Thiago L P, Marques Wanderson S, Ramos Rommel, Carneiro Adriana, de Sá Pablo, Miyoshi Anderson, Azevedo Vasco, Silva Artur
Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém-PA, Brazil.
Comput Struct Biotechnol J. 2013 Oct 13;6:e201303013. doi: 10.5936/csbj.201303013. eCollection 2013.
Since the first successful attempt at sequencing the Corynebacterium pseudotuberculosis genome, large amounts of genomic, transcriptomic and proteomic data have been generated. C. pseudotuberculosis is an interesting bacterium due to its great zoonotic potential and because it causes considerable economic losses worldwide. Furthermore, different strains of C. pseudotuberculosis are capable of causing various diseases in different hosts. Currently, we seek information about the phylogenetic relationships between different strains of C. pseudotuberculosis isolates from different hosts across the world and to employ these data to develop tools to diagnose and eradicate the diseases these strains cause. In this review, we present the latest findings on C. pseudotuberculosis that have been obtained with the most advanced techniques for sequencing and genomic organization. We also discuss the development of in silico tools for processing these data to prompt a better understanding of this pathogen.
自从首次成功尝试对伪结核棒状杆菌基因组进行测序以来,已产生了大量的基因组、转录组和蛋白质组数据。伪结核棒状杆菌是一种有趣的细菌,因其具有巨大的人畜共患病潜力,且在全球范围内造成相当大的经济损失。此外,不同菌株的伪结核棒状杆菌能够在不同宿主中引起各种疾病。目前,我们寻求有关来自世界各地不同宿主的伪结核棒状杆菌分离株不同菌株之间系统发育关系的信息,并利用这些数据开发工具来诊断和根除这些菌株引起的疾病。在这篇综述中,我们介绍了使用最先进的测序和基因组组织技术获得的关于伪结核棒状杆菌的最新发现。我们还讨论了用于处理这些数据的计算机工具的开发,以促进对这种病原体的更好理解。