Patel Samit A, Sunde Jan
Department of Obstetrics and Gynecology, Madigan Army Medical Center, 9040 Jackson Avenue, Tacoma, WA 98431.
Department of Obstetrics and Gynecology, Multicare Health System, 311 S L Street, Tacoma, WA 98405.
Mil Med. 2014 Apr;179(4):e461-2. doi: 10.7205/MILMED-D-13-00316.
A 54-year-old woman with a history of in-utero diethylstilbestrol (DES) exposure, who had a prior hysterectomy for symptomatic leiomyomata and dysmenorrhea, presented for vaginal bleeding. Vaginal biopsies showed a non-clear-cell adenocarcinoma, and the patient was subsequently treated with radiation therapy. We present a case of primary vaginal non-clear-cell adenocarcinoma in a patient with in-utero DES exposure. Continued monitoring of older DES-exposed women for vaginal lesions is warranted because of reported cases of non-clear-cell adenocarcinoma and persistent risk of clear cell adenocarcinoma.
一名有子宫内己烯雌酚（DES）暴露史的54岁女性，曾因症状性平滑肌瘤和痛经接受过子宫切除术，现因阴道出血前来就诊。阴道活检显示为非透明细胞腺癌，该患者随后接受了放射治疗。我们报告一例子宫内DES暴露患者发生原发性阴道非透明细胞腺癌的病例。鉴于有非透明细胞腺癌的报告病例以及透明细胞腺癌的持续风险，对有DES暴露史的老年女性持续监测阴道病变是必要的。
