Goodman A, Sullinger J C, Rice L W, Fuller A F
Department of Gynecology, Massachusetts General Hospital, Boston.
Gynecol Oncol. 1991 Nov;43(2):173-7. doi: 10.1016/0090-8258(91)90067-f.
A clear cell adenocarcinoma of the vaginal remnant in a diethylstilbestrol (DES)-exposed woman developed 20 years after anterior exenteration for a histologically similar stage II vaginal cancer. Arguments favoring a new primary cancer over a late recurrence are presented. This case probably represents the first report of a second primary vaginal clear cell cancer after DES exposure in utero. The implications of a second vaginal primary and the need for long-term surveillance in DES-exposed women are discussed.
一名曾接触己烯雌酚（DES）的女性，在因组织学相似的II期阴道癌接受前盆腔脏器清除术20年后，阴道残端发生了透明细胞腺癌。文中列举了支持这是一种新的原发性癌症而非晚期复发的论据。该病例可能是子宫内接触DES后发生第二原发性阴道透明细胞癌的首例报告。文中讨论了第二原发性阴道癌的意义以及对接触DES女性进行长期监测的必要性。
