Goena M, Santidrián S, Cuevillas F, Larralde J
Departamento de Fisiología Humana, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Rev Esp Fisiol. 1988 Dec;44(4):345-51.
Body weight gain, food intake, gastrocnemius muscle and liver weight, protein and RNA content, as well as the fractional rates of muscle and liver protein synthesis (ks, according to the method of constant infusion of L-[14C]tyrosine), growth (kg) and degradation (kd), along with RNA activity (g of protein synthesized per day/g RNA) of both organs, were determined in growing male rats fed ad libitum over a period of 10 days on 18.7% protein diets containing either casein (5% of methionine added) (control) or the raw legume field bean (Vicia faba L.) as the sole sources of protein. It has been found that as compared to control rats, those fed the raw legume diet exhibited a significant reduction in the rate of growth, muscle RNA, ks, kg, kd and RNA activity, and a significant increase in liver ks, kd and RNA activity. All differences were statistically significant at least at the 5% level. The possible nature of these findings is discussed.
在自由采食的生长雄性大鼠中，测定了体重增加、食物摄入量、腓肠肌和肝脏重量、蛋白质和RNA含量，以及肌肉和肝脏蛋白质合成的分数率（ks，根据L-[14C]酪氨酸持续输注法）、生长（kg）和降解（kd），以及两个器官的RNA活性（每天合成的蛋白质克数/克RNA）。这些大鼠在10天内随意进食含18.7%蛋白质的日粮，其中蛋白质来源分别为酪蛋白（添加5%蛋氨酸）（对照）或生豆科植物蚕豆（Vicia faba L.）。结果发现，与对照大鼠相比，喂食生豆科植物日粮的大鼠生长速率、肌肉RNA、ks、kg、kd和RNA活性显著降低，而肝脏ks、kd和RNA活性显著增加。所有差异至少在5%水平上具有统计学意义。讨论了这些发现可能的性质。
