Ordóñez N G, Zirkin R, Bloom R E
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Am J Surg Pathol. 1989 May;13(5):413-21. doi: 10.1097/00000478-198905000-00009.
A 28-year-old man with a large abdominal mass was found to have a tumor involving the peritoneum that had no other apparent primary origin. By light microscopy, the histologic pattern of the tumor was that of a small-cell epithelial neoplasm. Electron-microscopic examination demonstrated desmosomes and paranuclear aggregates of intermediate filaments. Immunohistochemical studies revealed reactivity for keratin, desmin, and vimentin. The globoid staining observed for the last two markers correlated with the paranuclear concentration of intermediate filaments observed by electron microscopy. We believe this case represents an unusual small-cell epithelial tumor, expressing mesenchymal-type intermediate filaments, that should be distinguished from other small-cell neoplasms.
一名28岁男性，腹部有一巨大肿块，发现其肿瘤累及腹膜，无其他明显的原发部位。光镜下，肿瘤的组织学形态为小细胞上皮性肿瘤。电镜检查显示有桥粒和中间丝的核旁聚集。免疫组化研究显示肿瘤细胞对角蛋白、结蛋白和波形蛋白呈阳性反应。后两种标志物的球状染色与电镜下观察到的中间丝核旁聚集相关。我们认为该病例代表了一种不寻常的小细胞上皮性肿瘤，表达间充质型中间丝，应与其他小细胞肿瘤相鉴别。
