Sharma Rohit, Kumar Vijay, Ashok B K, Galib R, Prajapati Pradeep Kumar, Ravishankar B
Ph.D. Scholar, Department of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, Gujarat, India.
Assistant Professor, Department of Pharmacology, Gurukul College of Pharmacy, Suratgarh, Rajasthan, India.
Ayu. 2013 Oct;34(4):417-20. doi: 10.4103/0974-8520.127726.
Over the centuries, herbs have served as a major source of medicines for prevention and treatment of diseases including diabetes mellitus. These herbs are getting more importance around the globe and many studies have provided safety and efficacy of such herbal drugs in different condition. Guduchi (Tinospora cordifolia [Willd.] Miers) is reported as highly potent Pramehahara (anti-diabetic) herb in Ayurveda and Guduchi Satva (GS) is popularly used to treat Paittika type of Prameha. In the present study, GS prepared from the stem of T. cordifolia was evaluated for hypoglycemic and anti-hyperglycemic activity in 18 h fasted mice. GS was suspended in distilled water and administered to animals at the dose of 130 mg/kg that showed the marginal reduction in blood sugar level (BSL) at all the time intervals in normoglycemic mice. In anti-hyperglycemic activity, administration of GS prior to glucose over load failed to attenuate BSL at all-time interval in comparison to glucose control group. The study concludes that mild hypoglycemic insignificant anti-hyperglycemic activities of GS.
几个世纪以来，草药一直是预防和治疗包括糖尿病在内的疾病的主要药物来源。这些草药在全球范围内越来越受到重视，许多研究已经证明了此类草药药物在不同情况下的安全性和有效性。古杜奇（心叶青牛胆 [Willd.] Miers）在阿育吠陀医学中被报道为具有高效能的抗糖尿病草药，古杜奇提取物（GS）被广泛用于治疗帕伊蒂卡型糖尿病。在本研究中，对从心叶青牛胆茎中制备的GS在禁食18小时的小鼠中进行了降血糖和抗高血糖活性评估。GS悬浮于蒸馏水中，以130mg/kg的剂量给予动物，该剂量在正常血糖小鼠的所有时间间隔内均显示出血糖水平（BSL）有轻微降低。在抗高血糖活性方面，与葡萄糖对照组相比，在葡萄糖负荷前给予GS未能在所有时间间隔内减弱BSL。该研究得出结论，GS具有轻微的降血糖作用，但抗高血糖活性不显著。
