炎症性肠病中的三叶因子
Trefoil factors in inflammatory bowel disease.
作者信息
Aamann Luise, Vestergaard Else Marie, Grønbæk Henning
机构信息
Luise Aamann, Henning Grønbæk, Department of Hepatology and Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
出版信息
World J Gastroenterol. 2014 Mar 28;20(12):3223-30. doi: 10.3748/wjg.v20.i12.3223.
Abstract
Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn's disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD.
摘要
炎症性肠病（IBD）包括溃疡性结肠炎和克罗恩病，其特征为胃肠道炎症。三叶因子1、2和3（TFF1 - 3）是一类肽，在包括胃肠道在内的上皮表面的保护和修复中发挥重要作用。TFFs可能参与IBD的发病机制，是一种潜在的治疗选择。在本综述中，我们通过总结目前关于它们在IBD中的表达、可能的功能和药理作用的知识，描述TFF家族及其在IBD中的潜在作用。
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