Ko Richard, Low Dog Tieraona, Gorecki Dennis K J, Cantilena Louis R, Costello Rebecca B, Evans William J, Hardy Mary L, Jordan Scott A, Maughan Ronald J, Rankin Janet W, Smith-Ryan Abbie E, Valerio Luis G, Jones Donnamaria, Deuster Patricia, Giancaspro Gabriel I, Sarma Nandakumara D
Nutr Rev. 2014 Mar;72(3):217-25. doi: 10.1111/nure.12087.
This Department of Defense-sponsored evidence-based review evaluates the safety and putative outcomes of enhancement of athletic performance or improved recovery from exhaustion in studies involving beta-alanine alone or in combination with other ingredients. Beta-alanine intervention studies and review articles were collected from 13 databases, and safety information was collected from adverse event reporting portals. Due to the lack of systematic studies involving military populations, all the available literature was assessed with a subgroup analysis of studies on athletes to determine if beta-alanine would be suitable for the military. Available literature provided only limited evidence concerning the benefits of beta-alanine use, and a majority of the studies were not designed to address safety. Overall, the strength of evidence in terms of the potential for risk of bias in the quality of the available literature, consistency, directness, and precision did not support the use of beta-alanine by military personnel. The strength of evidence for a causal relation between beta-alanine and paresthesia was moderate.
这项由美国国防部资助的循证综述评估了在仅涉及β-丙氨酸或其与其他成分联合使用的研究中，提高运动表现或改善疲劳恢复的安全性及假定结果。从13个数据库收集了β-丙氨酸干预研究和综述文章，并从不良事件报告平台收集了安全信息。由于缺乏涉及军事人群的系统研究，所有现有文献通过对运动员研究的亚组分析进行评估，以确定β-丙氨酸是否适用于军事人员。现有文献仅提供了关于使用β-丙氨酸益处的有限证据，并且大多数研究并非旨在解决安全性问题。总体而言，就现有文献质量、一致性、直接性和精确性方面存在偏倚风险的可能性而言，证据强度不支持军事人员使用β-丙氨酸。β-丙氨酸与感觉异常之间因果关系的证据强度为中等。
