白细胞介素-6与糖尿病及心血管并发症
IL-6 in diabetes and cardiovascular complications.
作者信息
Qu Dan, Liu Jian, Lau Chi Wai, Huang Yu
机构信息
Institute of Vascular Medicine, Shenzhen Research Institute, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
出版信息
Br J Pharmacol. 2014 Aug;171(15):3595-603. doi: 10.1111/bph.12713.
Abstract
IL-6 is a pleiotropic cytokine that participates in normal functions of the immune system, haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and cardiovascular diseases. Both pro- and anti-inflammatory roles of IL-6 have been described, which are distinguished by different cascades of signalling transduction, namely classic and trans-signalling. The present review summarizes the basic principles of IL-6 signalling and discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL-6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans-signalling of IL-6.
摘要
白细胞介素-6（IL-6）是一种多效性细胞因子，参与免疫系统的正常功能、造血作用、新陈代谢，以及代谢性疾病和心血管疾病的发病机制。IL-6的促炎和抗炎作用均有报道，二者通过不同的信号转导级联反应来区分，即经典信号转导和转信号转导。本综述总结了IL-6信号转导的基本原理，并讨论了其在糖尿病及相关心血管并发症中的作用，重点关注由两种IL-6信号转导模式介导的不同结果，以及开发特异性靶向IL-6有害转信号转导的治疗策略的价值。
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