Qu Dan, Liu Jian, Lau Chi Wai, Huang Yu
Institute of Vascular Medicine, Shenzhen Research Institute, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Br J Pharmacol. 2014 Aug;171(15):3595-603. doi: 10.1111/bph.12713.
IL-6 is a pleiotropic cytokine that participates in normal functions of the immune system, haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and cardiovascular diseases. Both pro- and anti-inflammatory roles of IL-6 have been described, which are distinguished by different cascades of signalling transduction, namely classic and trans-signalling. The present review summarizes the basic principles of IL-6 signalling and discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL-6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans-signalling of IL-6.
白细胞介素-6（IL-6）是一种多效性细胞因子，参与免疫系统的正常功能、造血作用、新陈代谢，以及代谢性疾病和心血管疾病的发病机制。IL-6的促炎和抗炎作用均有报道，二者通过不同的信号转导级联反应来区分，即经典信号转导和转信号转导。本综述总结了IL-6信号转导的基本原理，并讨论了其在糖尿病及相关心血管并发症中的作用，重点关注由两种IL-6信号转导模式介导的不同结果，以及开发特异性靶向IL-6有害转信号转导的治疗策略的价值。
