Murray G D, Lesaffre E
University Department of Surgery, Western Infirmary, University of Glasgow, Scotland.
J Cardiovasc Pharmacol. 1988;12 Suppl 8:S167-73.
Much of the literature concerning age-related effects in antihypertensive therapy suffers from serious deficiencies in statistical design and analysis. The problems include those relating to the choice of a suitable control group, the measurement of response to treatment, response to baseline blood pressure, interpreting post hoc analyses, and the pooling of data from a number of related studies. These problems are discussed and we attempt to identify solutions that give a satisfactory balance between scientific validity and the real-life problems of conducting clinical trials. We conclude by outlining a protocol for future studies in this area.
许多关于抗高血压治疗中年龄相关效应的文献在统计设计和分析方面存在严重缺陷。这些问题包括与合适对照组的选择、治疗反应的测量、对基线血压的反应、事后分析的解释以及多项相关研究的数据汇总有关的问题。本文对这些问题进行了讨论，并试图找出在科学有效性与开展临床试验的实际问题之间取得令人满意平衡的解决方案。我们最后概述了该领域未来研究的方案。
