Department of Physiology, University of Auckland, Auckland, New Zealand.
School of Medical Sciences, University of Auckland, New Zealand.
Life Sci. 2015 May 15;129:48-53. doi: 10.1016/j.lfs.2014.03.020. Epub 2014 Apr 1.
Diabetes elicits cardiac metabolic stress involving impaired glucose uptake and metabolic substrate shifts. Diabetic cardiac pathology is well documented in human patients and experimental animal models to be characterized by diastolic dysfunction, but the underlying mechanisms are not well understood. Signaling disturbances involved in cardiac insulin resistance are linked to glucose handling abnormalities. Both reversible (e.g. O-GlcNAc) and irreversible (e.g. AGEs) glucose-modifications of cardiomyocyte extracellular and intracellular proteins are implicated in structural and functional alterations underlying pathology in the diabetic heart. This review highlights some aspects of the epigenetic roles played by glucose (and related hexose sugars) in mediating diabetic cardiac pathology with specific consideration for the mechanisms impinging on post-translational modifications which have key signaling and mechanical impacts.
糖尿病引起心脏代谢应激，包括葡萄糖摄取受损和代谢底物转移。糖尿病性心脏病理学在人类患者和实验动物模型中已有充分记录，其特征为舒张功能障碍，但发病机制尚不清楚。与心脏胰岛素抵抗相关的信号转导紊乱与葡萄糖处理异常有关。心肌细胞细胞外和细胞内蛋白的可逆（例如 O-GlcNAc）和不可逆（例如 AGEs）葡萄糖修饰与糖尿病心脏病理学的结构和功能改变有关。这篇综述强调了葡萄糖（和相关六碳糖）在介导糖尿病性心脏病理学中的一些表观遗传作用，特别考虑了影响翻译后修饰的机制，这些机制对信号转导和机械作用具有关键影响。
