Pilutti Lara A, Dlugonski Deirdre, Sandroff Brian M, Klaren Rachel E, Motl Robert W
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL.
Department of Kinesiology, East Carolina University, Greenville, NC.
Arch Phys Med Rehabil. 2014 Jul;95(7):1283-8. doi: 10.1016/j.apmr.2014.03.015. Epub 2014 Mar 31.
To examine the efficacy of a physical activity behavioral intervention for improving outcomes of body composition in persons with multiple sclerosis (MS).
Secondary analysis of data from a randomized controlled trial.
University research laboratory.
Ambulatory persons with MS (N=82).
A 6-month, internet-delivered physical activity behavioral intervention designed to increase lifestyle physical activity, primarily walking. The behavioral intervention was based on principles of social cognitive theory.
Whole-body bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition, using dual-energy x-ray absorptiometry.
There were no significant differences between conditions posttrial on body composition outcomes using the adjusted critical value (P<.008). There was a significant effect of the intervention on whole-body BMC (P=.04, ω(2)<.001) and BMD (P=.01, ω(2)=.003) using the unadjusted critical value (P<.05). The effect of the intervention on percent body fat (P=.09, ω(2)=.001) and whole-body fat mass (P=.05, ω(2)=.003) approached significance using unadjusted criteria. There was not a significant effect on whole-body lean soft tissue (P=.28, ω(2)<.001) or body mass index (P=.86, ω(2)<.001).
Our results provide preliminary evidence that an internet-delivered lifestyle physical activity intervention might improve bone health and body composition in MS. Such findings are important considering that physical activity is a modifiable behavior with the potential to confer long-term benefits for the prevention and management of fracture risk and comorbidities among those with MS.
探讨体育活动行为干预对改善多发性硬化症（MS）患者身体成分指标的效果。
对一项随机对照试验的数据进行二次分析。
大学研究实验室。
能行走的MS患者（N = 82）。
一项为期6个月、通过互联网提供的体育活动行为干预，旨在增加生活方式中的体育活动，主要是步行。该行为干预基于社会认知理论原则。
使用双能X线吸收法测量全身骨矿物质含量（BMC）、骨矿物质密度（BMD）和软组织成分。
采用校正临界值时，试验后两组在身体成分指标上无显著差异（P <.008）。采用未校正临界值（P <.05）时，干预对全身BMC（P =.04，ω(2)<.001）和BMD（P =.01，ω(2)=.003）有显著影响。干预对体脂百分比（P =.09，ω(2)=.001）和全身脂肪量（P =.05，ω(2)=.003）的影响接近显著水平。对全身瘦软组织（P =.28，ω(2)<.001）或体重指数（P =.86，ω(2)<.001）无显著影响。
我们的结果提供了初步证据，表明通过互联网提供的生活方式体育活动干预可能改善MS患者的骨骼健康和身体成分。考虑到体育活动是一种可改变的行为，有可能为预防和管理MS患者的骨折风险及合并症带来长期益处，这些发现具有重要意义。
