苯妥英钠诱发急性泛发性脓疱性皮病伴小脑综合征的罕见病例。

Rare case of phenytoin induced acute generalized exanthematous pustulosis with cerebellar syndrome.

作者信息

Shingade Pravin U, Wankhede Vaishali, Kataria Pritam S, Sonone Nitin

机构信息

Department of Medicine, Government Medical College and Hospital, Nagpur, India.

Department of Skin and V. D., Government Medical College and Hospital, Nagpur, India.

出版信息

Indian J Dermatol. 2014 Mar;59(2):210. doi: 10.4103/0019-5154.127715.

DOI:10.4103/0019-5154.127715

PMID:24700960

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3969702/

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare drug induced cutaneous hypersensitivity reaction characterized by sudden onset of fever with sterile pustules overlying an erythematous skin occurring all over the body. The offending drugs are usually B-lactams and macrolides. Among anticonvulsants carbamazepine and Phenobarbital are commonly associated with AGEP. Only one case of phenytoin induced AGEP has been reported in literature. We present a rare case of AGEP with cerebellar syndrome occurring after receiving loading dose of phenytoin.

摘要

急性泛发性脓疱性皮病（AGEP）是一种罕见的药物引起的皮肤过敏反应，其特征为突然发热，全身出现红斑基础上的无菌性脓疱。致病药物通常为β-内酰胺类和大环内酯类。在抗惊厥药中，卡马西平和苯巴比妥常与AGEP相关。文献中仅报道过1例苯妥英钠诱发的AGEP。我们报告1例罕见的在接受苯妥英钠负荷剂量后发生的伴有小脑综合征的AGEP病例。