Pandit Deepa S, Khadilkar Anuradha V, Chiplonkar Shashi A, Khadilkar Vaman V, Kinare Arun S
Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India.
Indian J Endocrinol Metab. 2014 Jan;18(1):70-6. doi: 10.4103/2230-8210.126565.
To explore association of adiposity and physical activity with arterial stiffness and to propose optimal waist circumference cutoffs, corresponding to 90(th) percentile of NHANES (National Health and Nutrition Examination Survey) for Indian children and adolescents.
Data on weight, height, waist circumference, physical activity and right Carotid artery Intima-Media-Thickness (CIMT), pulse wave velocity (PWV), elasticity modulus (Ep), stiffness index(β), arterial compliance (AC) were assessed in 250 children (72 normal-weight and 178 overweight/obese) aged 6-17 years from Pune city, India. Body composition was measured using Dual energy X-ray absorptiometry.
Total, 37.1% normal-weight and 98.2% overweight/obese children had high adiposity (>95(th) body fat percentile). Positive association of PWV and Ep (r = 0.5) also β(r = 0.25) with BMI (Body Mass Index), waist circumference and body fat (P < 0.05) was observed. Physical activity was inversely associated with PWV (r =-0.2), β(r =-0.13), Ep (r =-0.12) and positively with AC (r = 0.12) (P < 0.05). PWV significantly increased with increasing body fat for each tertile of physical activity (P < 0.05). Regression analysis revealed waist circumference, BMI, body fat and physical activity as independent associates for PWV after adjusting for age (P < 0.05). The cutoff of waist circumference yielding sensitivity and specificity for predicting the risk of high PWV was (-0.43, -0.44) for boys and girls with sensitivity in boys (girls) of 78% (87%) and specificity in boys (girls) 51% (70%). The observed cutoffs are less than the NHANES-III cutoff values of waist circumference for 90(th) percentiles according to age and sex.
High adiposity and low physical activity are adversely related to arterial stiffness in Indian children.
探讨肥胖和身体活动与动脉僵硬度之间的关联，并提出对应于美国国家健康与营养检查调查（NHANES）第90百分位数的印度儿童和青少年的最佳腰围临界值。
对来自印度浦那市的250名6至17岁儿童（72名体重正常和178名超重/肥胖）的体重、身高、腰围、身体活动以及右侧颈动脉内膜中层厚度（CIMT）、脉搏波速度（PWV）、弹性模量（Ep）、僵硬度指数（β）、动脉顺应性（AC）进行评估。使用双能X线吸收法测量身体成分。
总体而言，37.1%体重正常和98.2%超重/肥胖儿童有高肥胖度（>第95百分位体脂）。观察到PWV和Ep（r = 0.5）以及β（r = 0.25）与体重指数（BMI）、腰围和体脂呈正相关（P < 0.05）。身体活动与PWV（r = -0.2）、β（r = -0.13）、Ep（r = -0.12）呈负相关，与AC呈正相关（r = 0.12）（P < 0.05）。对于身体活动的每个三分位数，PWV随体脂增加而显著增加（P < 0.05）。回归分析显示，在调整年龄后，腰围、BMI、体脂和身体活动是PWV的独立相关因素（P < 0.05）。预测高PWV风险的腰围临界值，男孩和女孩分别为（-0.43，-0.44），男孩的敏感性为78%，女孩为87%；男孩的特异性为51%，女孩为70%。观察到的临界值低于NHANES - III根据年龄和性别划分的第90百分位数的腰围临界值。
在印度儿童中，高肥胖度和低身体活动与动脉僵硬度呈负相关。
