Mannan Rahul, Bhasin Tejinder Singh, Kaur Parampreet, Manjari Mridu, Gill Karamjit Singh
Asociate Profesor, Sri Guru Ram Das Institute of Medical Sciences and Research , Amritsar, Punjab, India .
Professor, Sri Guru Ram Das Institute of Medical Sciences and Research , Amritsar, Punjab, India .
J Clin Diagn Res. 2014 Feb;8(2):145-6. doi: 10.7860/JCDR/2014/6577.4035. Epub 2014 Feb 3.
Alveolar soft part sarcoma (ASPS) is a rare neoplasm of unknown histogenesis with poor prognosis. Due to the epithelioid appearance of the neoplastic cells, ASPS may resemble many neoplastic conditions, such as metastatic epithelial cell tumours with clear cell change, metastatic renal cell carcinoma, granular cell tumour, epithelioid sarcoma, malignant melanoma and even paragangliomas. Presence of abundant, rod like crystals in the cytoplasm of tumour cells is an important finding characteristic of this tumour, which helps in differentiating it from the other entities. The case study highlights the importance of correlating cytological features that help in reaching the diagnosis such as the background, cell morphology and presence of characteristic rod shaped crystals as immunohistochemical studies are often non-conclusive. The case also is unique as it demonstrates presence of intra-cytoplamic crystals in such abundance.
肺泡软组织肉瘤（ASPS）是一种组织发生不明的罕见肿瘤，预后较差。由于肿瘤细胞呈上皮样外观，ASPS可能类似于许多肿瘤性疾病，如伴有透明细胞改变的转移性上皮细胞肿瘤、转移性肾细胞癌、颗粒细胞瘤、上皮样肉瘤、恶性黑色素瘤甚至副神经节瘤。肿瘤细胞胞质内存在丰富的杆状晶体是该肿瘤的一个重要特征性发现，有助于将其与其他实体肿瘤区分开来。该病例研究强调了将有助于诊断的细胞学特征（如背景、细胞形态和特征性杆状晶体的存在）相互关联的重要性，因为免疫组织化学研究往往没有定论。该病例也很独特，因为它显示出胞质内晶体如此丰富。
