Xiong Yang, Zhang Xuxue, Huang Tao, Cao Song
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
J Org Chem. 2014 Jul 18;79(14):6395-402. doi: 10.1021/jo5005845. Epub 2014 Apr 4.
A mild and versatile method for the construction of C-N bonds by the reaction of (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 °C) affording the (E)-N-α-fluorovinyl derivatives of azoles 3 in good to excellent yields with relatively high stereoselectivity.
