生活方式因素与青春期前儿童血清脱氢表雄酮硫酸酯和胰岛素样生长因子-1浓度的相关性。
Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children.
机构信息
Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Department of Physiology, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
出版信息
Clin Endocrinol (Oxf). 2018 Feb;88(2):234-242. doi: 10.1111/cen.13511. Epub 2017 Nov 29.
OBJECTIVE
Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEAS and IGF-1 in children.
DESIGN AND SUBJECTS
Cross-sectional analysis of a population sample of 431 prepubertal children aged 6-9 years.
MEASUREMENTS
Assessment of dietary factors by food records and physical activity and sedentary behaviour by a combined heart rate and movement monitor and a questionnaire. Measurement of serum DHEAS and IGF-1.
RESULTS
Consumption of low-fibre grain products (standardized regression coefficient β = .118, P = .017) and intake of vegetable protein (β = .100, P = .045) was positively and consumption of sugar-sweetened beverages (β = -.117, P = .018) was inversely associated with DHEAS after adjustment for sex, age and body fat percentage. Energy intake (β = .160, P = .001) was positively associated with IGF-1 adjusting for sex, age and body fat percentage. Vigorous physical activity was inversely associated with DHEAS after adjustment for sex and age (β = -.120, P = .027), and total (β = -.137, P = .007), moderate (β = -.130, P = .012), vigorous (β = -.136, P = .011) and moderate to vigorous physical activity (β = -.160, P = .003) were inversely and total sedentary behaviour (β = .151, P = .003) was positively associated with IGF-1 adjusting for sex and age. None of physical activity measures was associated with DHEAS or IGF-1 after additional adjustment for body fat percentage.
CONCLUSIONS
Lifestyle factors have weak and moderate associations with biochemical markers of adrenarche in prepubertal children. These associations indicate body fat independent and dependent influences of diet and physical activity, respectively.
目的
对于青春期前儿童，有关饮食因素、身体活动和久坐行为与硫酸脱氢表雄酮（DHEAS）和胰岛素样生长因子-1（IGF-1）浓度之间关系的信息有限。因此，我们研究了这些生活方式因素与儿童血清 DHEAS 和 IGF-1 的相关性。
设计和研究对象
对 431 名 6-9 岁青春期前儿童的人群样本进行横断面分析。
测量方法
通过食物记录评估饮食因素，通过心率和运动监测器以及问卷评估身体活动和久坐行为。测量血清 DHEAS 和 IGF-1。
结果
调整性别、年龄和体脂百分比后，低纤维谷物制品的摄入量（标准化回归系数β=0.118，P=0.017）和蔬菜蛋白的摄入量（β=0.100，P=0.045）与 DHEAS 呈正相关，而含糖饮料的摄入量（β=-0.117，P=0.018）与 DHEAS 呈负相关。调整性别、年龄和体脂百分比后，能量摄入（β=0.160，P=0.001）与 IGF-1 呈正相关。调整性别和年龄后，剧烈身体活动与 DHEAS 呈负相关（β=-0.120，P=0.027），总身体活动（β=-0.137，P=0.007）、中度身体活动（β=-0.130，P=0.012）、剧烈身体活动（β=-0.136，P=0.011）和中高强度身体活动（β=-0.160，P=0.003）与 DHEAS 呈负相关，而总久坐行为（β=0.151，P=0.003）与 IGF-1 呈正相关，调整性别和年龄后。在进一步调整体脂百分比后，没有任何身体活动测量指标与 DHEAS 或 IGF-1 相关。
结论
生活方式因素与青春期前儿童的肾上腺功能初现生化标志物有弱相关和中度相关。这些关联表明，饮食和身体活动分别对体脂具有独立和依赖的影响。
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