School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, Yunnan, People's Republic of China.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Fitoterapia. 2014 Jun;95:214-9. doi: 10.1016/j.fitote.2014.03.026. Epub 2014 Apr 4.
Five unusual new prenylated chalcones, renifolins D-H (1-5), were isolated from whole Desmodium renifolium plants. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. All of the isolates were evaluated for cytotoxicity using five tumor cell lines. Compounds 2 and 3 exhibited cytotoxicity against A549 cells, with IC50 values of 2.8 and 2.2 μM, respectively.
从全株毛果鱼藤中分离得到五个新的prenylated chalcones，分别命名为 renifolins D-H (1-5)。通过 1D 和 2D NMR 等光谱方法确定了它们的结构。所有分离物均采用五种肿瘤细胞系进行细胞毒性评价。化合物 2 和 3 对 A549 细胞表现出细胞毒性，IC50 值分别为 2.8 和 2.2 μM。
