逆转录病毒作为移动遗传因子的病理和进化意义。
Pathological and evolutionary implications of retroviruses as mobile genetic elements.
机构信息
Department of Biology, Colorado State University, 801 Oval Drive, Fort Collins, CO 80523, USA.
Department of Environmental and Radiological Health Sciences, Colorado State University, 801 Oval Drive, Fort Collins, CO 80523, USA.
出版信息
Genes (Basel). 2013 Oct 24;4(4):573-82. doi: 10.3390/genes4040573.
Retroviruses, a form of mobile genetic elements, have important roles in disease and primate evolution. Exogenous retroviruses, such as human immunodeficiency virus (HIV), have significant pathological implications that have created a massive public health challenge in recent years. Endogenous retroviruses (ERVs), which are the primary focus of this review, can also be pathogenic, as well as being beneficial to a host in some cases. Furthermore, retroviruses may have played a key role in primate evolution that resulted in the incorporation of these elements into the human genome. Retroviruses are mobile genetic elements that have important roles in disease and primate evolution. We will further discuss the pathogenic potential of retroviruses, including their role in cancer biology, and will briefly summarize their evolutionary implications.
逆转录病毒是一种移动遗传元件，在疾病和灵长类动物进化中具有重要作用。外源性逆转录病毒，如人类免疫缺陷病毒 (HIV)，具有重要的病理学意义，近年来给公共卫生带来了巨大挑战。内源性逆转录病毒 (ERV) 是本次综述的主要关注点，它们也可能具有致病性，在某些情况下对宿主有益。此外，逆转录病毒可能在灵长类动物进化中发挥了关键作用，导致这些元件被整合到人类基因组中。逆转录病毒是一种移动遗传元件，在疾病和灵长类动物进化中具有重要作用。我们将进一步讨论逆转录病毒的致病潜力，包括它们在癌症生物学中的作用，并简要总结它们的进化意义。
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