Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.
Mol Syst Biol. 2014 Apr 4;10(4):723. doi: 10.1002/msb.145202.
The reasons why some DNA replication origins fire earlier than others have remained elusive. New work by Gindin et al suggests that the distribution of replication origins, not their timing per se, is the major determinant of the timing of genome replication in human cells.
为什么有些 DNA 复制起点比其他起点更早启动一直是个谜。Gindin 等人的新研究表明,复制起点的分布,而不是它们的时间本身,是人类细胞基因组复制时间的主要决定因素。