Anghel Ion, Holban Alina Maria, Andronescu Ecaterina, Grumezescu Alexandru Mihai, Chifiriuc Mariana Carmen
ENT, "Carol Davila" University of Medicine and Pharmacy, TraianVuia no.6, Bucharest, 020956, Romania,
Biointerphases. 2013 Dec;8(1):12. doi: 10.1186/1559-4106-8-12. Epub 2013 Apr 25.
The present study reports the fabrication and characterization of a novel nanostructured phyto-bioactive coated rayon/polyester wound dressing (WD) surface refractory to Candida albicans adhesion, colonization and biofilm formation, based on functionalized magnetite nanoparticles and Anethum graveolens (AG) and Salvia officinalis (SO) essential oils (EOs). TEM, XRD, TGA, FT-IR were used for the characterization of the fabricated nanobiocoated WDs. Using magnetic nanoparticles for the stabilization and controlled release of EOs, the activity of natural volatile compounds is significantly enhanced and their effect is stable during time. For this reason the nanobiocoated surfaces exhibited a longer term anti-biofilm effect, maintained for at least 72 h. Besides their excellent anti- adherence properties, the proposed solutions exhibit the advantage of using vegetal natural compounds, which are less toxic and easily biodegradable in comparison with synthetic antifungal drugs, representing thus promising approaches for the development of successful ways to control and prevent fungal biofilms associated infections.
本研究报告了一种新型纳米结构植物生物活性涂层粘胶/聚酯伤口敷料（WD）的制备与表征，该敷料基于功能化磁铁矿纳米颗粒以及莳萝（AG）和鼠尾草（SO）精油（EOs），对白色念珠菌的粘附、定植和生物膜形成具有表面抗性。采用透射电子显微镜（TEM）、X射线衍射（XRD）、热重分析（TGA）、傅里叶变换红外光谱（FT-IR）对制备的纳米生物涂层伤口敷料进行表征。利用磁性纳米颗粒对精油进行稳定化和控释，天然挥发性化合物的活性显著增强，且其效果在一段时间内保持稳定。因此，纳米生物涂层表面表现出更长时间的抗生物膜效果，至少持续72小时。除了具有优异的抗粘附性能外，所提出的解决方案还具有使用植物天然化合物的优势，与合成抗真菌药物相比，这些化合物毒性较小且易于生物降解，因此是开发控制和预防真菌生物膜相关感染成功方法的有前景的途径。
