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MAPLE制造的用于改良胃造口管的Fe3O4@肉桂抗菌表面。

MAPLE fabricated Fe3O4@Cinnamomum verum antimicrobial surfaces for improved gastrostomy tubes.

作者信息

Anghel Alina Georgiana, Grumezescu Alexandru Mihai, Chirea Mariana, Grumezescu Valentina, Socol Gabriel, Iordache Florin, Oprea Alexandra Elena, Anghel Ion, Holban Alina Maria

机构信息

ENT, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania.

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania.

出版信息

Molecules. 2014 Jun 27;19(7):8981-94. doi: 10.3390/molecules19078981.

DOI:10.3390/molecules19078981
PMID:24979402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6271288/
Abstract

Cinnamomum verum-functionalized Fe3O4 nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe3O4@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization.

摘要

通过基质辅助脉冲激光蒸发（MAPLE）技术将尺寸为9.4纳米的肉桂功能化四氧化三铁纳米颗粒激光转移到胃造口管（G管）上，以评估其对革兰氏阳性和革兰氏阴性微生物定植的抗菌活性。纳米颗粒粉末的X射线衍射分析显示为多晶磁铁矿结构，而红外映射证实了激光转移后肉桂（CV）官能团的完整性。沉积膜的特定形貌包括均匀的薄涂层以及覆盖G管的生物功能化磁铁矿颗粒的几个聚集体。细胞毒性试验表明，Fe3O4@CV处理后G管表面生物相容性增加，使内皮细胞在长达五天的培养中能正常发育。对纳米颗粒修饰的G管表面进行的微生物学试验证明其抗粘附性能有所改善，显著减少了革兰氏阴性和革兰氏阳性细菌的定植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7f/6271288/998501930e51/molecules-19-08981-g011.jpg
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